Allopurinol Therapy of Gout with Renal Complications
نویسندگان
چکیده
منابع مشابه
Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
Gout is an often forgotten disease, despite being the most common inflammatory arthritis in adults in the Western world. Lesinurad, a new urate-lowering therapy (ULT), is now approved for the treatment of gout in the USA and the European Union, 6 and is in phase III programmes as a combination therapy in many other countries. Lesinurad is a selective inhibitor of urate/anion exchanger 1 and org...
متن کاملWithdrawal of allopurinol in patients with gout.
The xanthine oxidase inhibitor allopurinol effectively lowers the plasma level of uric acid and the drug has become widely used in the treatment of gout, especially in patients with renal failure, uric acid calculi, or intolerance to uricosuric agents (Scott, Hall, and Grahame, 1966). Various theoretical complications of treatment have been considered from time to time, such as possible incorpo...
متن کاملRelation between adverse events associated with allopurinol and renal function in patients with gout.
BACKGROUND Because serious adverse reactions to allopurinol have been related to a reduce creatinine clearance rate and prolonged half life of oxypurinol, it has been recommended that the dose should be adjusted according to the rate of creatinine clearance. However, in some patients with gout the dose is not sufficient to reduce serum levels of uric acid (< or =390 micromol/l) and to halt dise...
متن کاملTreatment of gout with allopurinol and sulphinpyrazone in combination and with allopurinol alone.
Successful long-term management of primary gout in the presence of normal renal function may be achieved in most instances by agents which diminish tubular reabsorption of urates, thus permitting increased urinary urate excretion. In recent years the two most widely used uricosuric agents have been probenecid and sulphinpyrazone. The easiest longterm control of gout with the fewest untoward sid...
متن کاملFebuxostat compared with allopurinol in patients with hyperuricemia and gout.
BACKGROUND Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout. METHODS We randomly assigned 762 patients with gout and with serum urate concentrations of at least 8.0 mg per deciliter (480 micromol per liter) to receive either febuxostat (80 mg or 120 mg) or allopurinol (300 mg) once daily f...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1966
ISSN: 0003-4967
DOI: 10.1136/ard.25.suppl_6.688